Global spatial dynamics and vaccine-induced fitness changes of Bordetella pertussis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F22%3A00013855" target="_blank" >RIV/75010330:_____/22:00013855 - isvavai.cz</a>
Result on the web
<a href="https://www.science.org/doi/10.1126/scitranslmed.abn3253" target="_blank" >https://www.science.org/doi/10.1126/scitranslmed.abn3253</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1126/scitranslmed.abn3253" target="_blank" >10.1126/scitranslmed.abn3253</a>

Result language
angličtina
Original language name
Global spatial dynamics and vaccine-induced fitness changes of Bordetella pertussis
Original language description
As with other pathogens, competitive interactions between Bordetella pertussis strains drive infection risk. Vaccines are thought to perturb strain diversity through shifts in immune pressures; however, this has rarely been measured because of inadequate data and analytical tools. We used 3344 sequences from 23 countries to show that, on average, there are 28.1 transmission chains circulating within a subnational region, with the number of chains strongly associated with host population size. It took 5 to 10 years for B. pertussis to be homogeneously distributed throughout Europe, with the same time frame required for the United States. Increased fitness of pertactin-deficient strains after implementation of acellular vaccines, but reduced fitness otherwise, can explain long-term genotype dynamics. These findings highlight the role of vaccine policy in shifting local diversity of a pathogen that is responsible for 160,000 deaths annually.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30303 - Infectious Diseases

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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