Cold plasma: The way to improve the SALD ICP MS analysis repeatibility

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F17%3A00095326" target="_blank" >RIV/00216224:14310/17:00095326 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Cold plasma: The way to improve the SALD ICP MS analysis repeatibility
Original language description
This work deals with the preparation of model biological microsamples for Substrate Assisted Laser Desorption Inductively Coupled Plasma Mass Spectrometry (SALD ICP MS). This technique provides direct and fast analysis of liquid samples deposited onto polyethylene terephthalate (PET) plate (substrate) in the form of dried droplets with minimal sample preparation and submicrolitre sample volume requirements. Furthermore, SALD allows direct analysis of samples in organic solvents, which cannot be directly nebulised to ICP MS. These benefits are, however, balanced out by low repeatability of the assay, typically about 30 %. One of the approaches to increasing the repeatability is a modification of the substrate surface by Diffuse Coplanar Surface Barrier Discharge (DCSBD) with an addition of an internal standard to the sample. Using this approach, a relative standard deviation under 10 % for model biological samples can be achieved. The only limitation of this technique is the occurrence of the so-called “aging effect”, i.e., the gradual return of the modified physicochemical surface properties to the original state.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
CECE 2017 14th International Interdisciplinary Meeting on Bioanalysis
ISBN
9789633961032
ISSN
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e-ISSN
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Number of pages
167
Pages from-to
143-147
Publisher name
MTA-PE Translational Glycomics Research Group, Research Institute for Biomolecular and Chemical Engineering, University of Pannonia Egyetem u. 10, H-8200 Veszprém, Hungary
Place of publication
Veszprém, Hungary
Event location
Veszprém, Hungary
Event date
Oct 8, 2017
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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