All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Retinoid-like compounds produced by phytoplankton affect embryonic development of Xenopus laevis

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F17%3A00095556" target="_blank" >RIV/00216224:14310/17:00095556 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.sciencedirect.com/science/article/pii/S0147651316305309?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0147651316305309?via%3Dihub</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.ecoenv.2016.12.018" target="_blank" >10.1016/j.ecoenv.2016.12.018</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Retinoid-like compounds produced by phytoplankton affect embryonic development of Xenopus laevis

  • Original language description

    Teratogenic effects, which were remarkably similar to those induced by retinoic acids, have been seen in wild frogs indicating possible source of retinoids in the environment. Recent studies indicate that some cyanobacterial species can contain teratogenic retinoic acids (RAs) and their analogues. Retinoids are known to regulate important processes such as differentiation, development, and embryogenesis. The study investigated the effects of exudates (extracellular compounds) of two cyanobacteria species with retinoic-like activity and one algae species on embryonic development of amphibians. The retinoid-like activity determined by in vitro reporter gene assay reached 528 ng retinoid equivalents (REQ)/L and 1000 ng REQ/L in exudates of Cylindrospermopsis raciborskii and Microcystis aeruginosa, respectively, while algal exudates showed no detectable activity. Total mean of retinoid-like copounds into exudate was 35.6 ng ATRA/mil.cells for M. aeruginosa and 6.71 ng ATRA/mil.cells for C.racibotskii, respectively. Toxicity tests with amphibian embryos up to 96 h of development were carried out according to the standard guide for the Frog Embryo Teratogenesis Assay Xenopus. Lowest observed effect concentrations (LOEC) of malformations (2.5-2.6 mu g/REQ) were two times lower than LOEC for ATRA (5 mu g/L). The exudates of both cyanobacteria were indeed provoking diverse teratogenic effects (e.g. tail, gut and eyes deformation) and interference with growth in frogs embryos, while such effects were not observed for the algae. Xenopus embryos were also exposed to all-trans retinoic acid (ATRA) in concentration range (1-40 mu g/L) equivalent to the REQs detected in cyanobacterial exudates. ATRA (10 mu g/L) caused similar teratogenic phenotypes at corresponding REQs as cyanobacterial exudates. The study confirms the ability of some species of cyanobacteria to produce retinoids naturally and excrete them directly into the environment at concentrations which might have adverse influence on the development of amphibians.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10511 - Environmental sciences (social aspects to be 5.7)

Result continuities

  • Project

    <a href="/en/project/GP14-29370P" target="_blank" >GP14-29370P: Common cyanobacterial species as producers of teratogenic retinoid compounds</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Ecotoxicology and Environmental Safety

  • ISSN

    0147-6513

  • e-ISSN

  • Volume of the periodical

    138

  • Issue of the periodical within the volume

    April

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    7

  • Pages from-to

    32-38

  • UT code for WoS article

    000394561600005

  • EID of the result in the Scopus database