Retinoid-like activity and teratogenic effects of cyanobacterial exudates
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F14%3A00074441" target="_blank" >RIV/00216224:14310/14:00074441 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0166445X14002355" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0166445X14002355</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.aquatox.2014.06.022" target="_blank" >10.1016/j.aquatox.2014.06.022</a>
Alternative languages
Result language
angličtina
Original language name
Retinoid-like activity and teratogenic effects of cyanobacterial exudates
Original language description
Given the essential role of retinoids for vertebrate development this has raised concerns about a potential risk for vertebrates exposed to retinoids during cyanobacterial blooms. Our study focuses on extracellular compounds produced by phytoplankton cells (exudates). In order to address the capacity for the production of retinoids or compounds with retinoid-like activity we compared the exudates of ten cyanobacteria and algae using in vitro reporter gene assay. Exudates of three cyanobacterial speciesshowed retinoid-like activity in the range of 269-2265 ng retinoid equivalents (REQ)/L, while there was no detectable activity in exudates of the investigated algal species. The exudates of one green alga (Desmodesmus quadricaudus) and the two cyanobacterial species with greatest REQ levels, Microgstis aeruginosa and Cylindrospermopsis raciborskii, were selected for testing of the potential relation of retinoid-like activity to developmental toxicity in zebrafish embryos.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
DJ - Pollution and water control
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/GAP503%2F12%2F0553" target="_blank" >GAP503/12/0553: Endocrine disruptive potential of cyanobacterial metabolites</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Aquatic toxicology
ISSN
0166-445X
e-ISSN
—
Volume of the periodical
155
Issue of the periodical within the volume
OCTOBER
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
283-290
UT code for WoS article
000342245300032
EID of the result in the Scopus database
—