Multi-Enzyme Pathway Optimisation Through Star-Shaped Reachable Sets

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F17%3A00099434" target="_blank" >RIV/00216224:14310/17:00099434 - isvavai.cz</a>
Result on the web
<a href="https://loschmidt.chemi.muni.cz/peg/wp-content/uploads/2017/10/9783319608150-c2.pdf" target="_blank" >https://loschmidt.chemi.muni.cz/peg/wp-content/uploads/2017/10/9783319608150-c2.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-319-60816-7_2" target="_blank" >10.1007/978-3-319-60816-7_2</a>

Result language
angličtina
Original language name
Multi-Enzyme Pathway Optimisation Through Star-Shaped Reachable Sets
Original language description
This article studies the time evolution of multi-enzyme pathways. The non-linearity of the problem coupled with the infinite dimensionality of the time-dependent input usually results in a rather laborious optimization. Here we discuss how the optimization of the input enzyme concentrations might be efficiently reduced to a calculation of reachable sets. Under some general conditions, the original system has star-shaped reachable sets that can be derived by solving a partial differential equation. This method allows a thorough study and optimization of quite sophisticated enzymatic pathways with non-linear dynamics and possible inhibition. Moreover, optimal control synthesis based on reachable sets can be implemented and was tested on several simulated examples.
Czech name
—
Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
11th International Conference on Practical Applications of Computational Biology & Bioinformatics
ISBN
9783319608167
ISSN
2194-5357
e-ISSN
—
Number of pages
9
Pages from-to
9-17
Publisher name
Springer International Publishing
Place of publication
Německo
Event location
Porto, Portugal
Event date
Jun 23, 2017
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000465514300002

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