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Multi-Enzyme Pathway Optimisation Through Star-Shaped Reachable Sets

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F17%3A00099434" target="_blank" >RIV/00216224:14310/17:00099434 - isvavai.cz</a>

  • Result on the web

    <a href="https://loschmidt.chemi.muni.cz/peg/wp-content/uploads/2017/10/9783319608150-c2.pdf" target="_blank" >https://loschmidt.chemi.muni.cz/peg/wp-content/uploads/2017/10/9783319608150-c2.pdf</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/978-3-319-60816-7_2" target="_blank" >10.1007/978-3-319-60816-7_2</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Multi-Enzyme Pathway Optimisation Through Star-Shaped Reachable Sets

  • Original language description

    This article studies the time evolution of multi-enzyme pathways. The non-linearity of the problem coupled with the infinite dimensionality of the time-dependent input usually results in a rather laborious optimization. Here we discuss how the optimization of the input enzyme concentrations might be efficiently reduced to a calculation of reachable sets. Under some general conditions, the original system has star-shaped reachable sets that can be derived by solving a partial differential equation. This method allows a thorough study and optimization of quite sophisticated enzymatic pathways with non-linear dynamics and possible inhibition. Moreover, optimal control synthesis based on reachable sets can be implemented and was tested on several simulated examples.

  • Czech name

  • Czech description

Classification

  • Type

    D - Article in proceedings

  • CEP classification

  • OECD FORD branch

    10102 - Applied mathematics

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    11th International Conference on Practical Applications of Computational Biology & Bioinformatics

  • ISBN

    9783319608167

  • ISSN

    2194-5357

  • e-ISSN

  • Number of pages

    9

  • Pages from-to

    9-17

  • Publisher name

    Springer International Publishing

  • Place of publication

    Německo

  • Event location

    Porto, Portugal

  • Event date

    Jun 23, 2017

  • Type of event by nationality

    WRD - Celosvětová akce

  • UT code for WoS article

    000465514300002