Structure-function Relationships and Engineering of Haloalkane Dehalogenases.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F17%3A00100792" target="_blank" >RIV/00216224:14310/17:00100792 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/978-3-319-39782-5" target="_blank" >http://dx.doi.org/10.1007/978-3-319-39782-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-319-39782-5" target="_blank" >10.1007/978-3-319-39782-5</a>
Alternative languages
Result language
angličtina
Original language name
Structure-function Relationships and Engineering of Haloalkane Dehalogenases.
Original language description
The structure-function relationships for haloalkane dehalogenases, one of the best characterized enzyme families involved in degradation of halogenated compounds, is described. A substantial amount of mechanistic and structural information is currently available on haloalkane dehalogenases, providing good theoretical framework for their modification by protein engineering. Examples of constructed mutants include variants with modified: (i) activity and specificity, (ii) stability, and (ii) enantioselectivity. Many variants carried mutations in the tunnels connecting the buried active site with surrounding solvent, rather than in the active site itself. Mutagenesis of residues lining the protein tunnels represents attractive and a viable approach of protein engineering.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
HANDBOOK OF HYDROCARBON AND LIPID MICROBIOLOGY SERIES. AEROBIC UTILIZATION OF HYDROCARBONS, OILS, AND LIPIDS
ISBN
9783319504193
Number of pages of the result
21
Pages from-to
1-21
Number of pages of the book
859
Publisher name
Springer, Cham
Place of publication
Heidelberg
UT code for WoS chapter
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