Structure-Function Relationships and Engineering of Haloalkane Dehalogenases

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F19%3A00119131" target="_blank" >RIV/00216224:14310/19:00119131 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1007/978-3-319-50418-6_15" target="_blank" >https://doi.org/10.1007/978-3-319-50418-6_15</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-319-50418-6_15" target="_blank" >10.1007/978-3-319-50418-6_15</a>

Result language
angličtina
Original language name
Structure-Function Relationships and Engineering of Haloalkane Dehalogenases
Original language description
The structure-function relationships for haloalkane dehalogenases, one of the best characterized enzyme families involved in degradation of halogenated compounds, are described. A substantial amount of mechanistic and structural information is currently available on haloalkane dehalogenases, providing good theoretical framework for their modification by protein engineering. Examples of constructed mutants include variants with modified (i) activity and specificity, (ii) stability, and (ii) enantioselectivity. Many variants carried mutations in the tunnels connecting the buried active site with surrounding solvent, rather than in the active site itself. Mutagenesis of residues lining the protein tunnels represents attractive and a viable approach of protein engineering.
Czech name
—
Czech description
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)