Oil-based adjuvants delivered intradermally induce high primary IgG2 immune response in swine
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F17%3A00111749" target="_blank" >RIV/00216224:14310/17:00111749 - isvavai.cz</a>
Alternative codes found
RIV/00027162:_____/17:N0000016
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0034528817300474?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0034528817300474?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.rvsc.2017.03.007" target="_blank" >10.1016/j.rvsc.2017.03.007</a>
Alternative languages
Result language
angličtina
Original language name
Oil-based adjuvants delivered intradermally induce high primary IgG2 immune response in swine
Original language description
The effects of intradermal application of antigen with or without different adjuvants and activation of immune response are presented in this study. Six groups of six piglets each were immunized with keyhole limpet haemocyanin (KLH) antigen in combination with aluminium hydroxide or oil-based adjuvants (complete and incomplete Freund's adjuvants, Montanide ISA 206 and Emulsigen). IgG1 and IgG2 levels in sera were measured by KLH-specific ELISA. Interestingly, oil-based adjuvants induced high primary IgG2 response, suggesting the Thl lymphocyte polarization. Also, considering the similarities between human and porcine organism, we suggest that intradermal application could be considered as an effective vaccine delivery route in both veterinary and human medicine.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40301 - Veterinary science
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
RESEARCH IN VETERINARY SCIENCE
ISSN
0034-5288
e-ISSN
1532-2661
Volume of the periodical
114
Issue of the periodical within the volume
OCT
Country of publishing house
GB - UNITED KINGDOM
Number of pages
3
Pages from-to
41-43
UT code for WoS article
000414881800008
EID of the result in the Scopus database
2-s2.0-85015435515