An armadillo-domain protein participates in a telomerase interaction network

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F18%3A00101550" target="_blank" >RIV/00216224:14310/18:00101550 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/18:00502448 RIV/61389030:_____/18:00502448
Result on the web
<a href="http://dx.doi.org/10.1007/s11103-018-0747-4" target="_blank" >http://dx.doi.org/10.1007/s11103-018-0747-4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11103-018-0747-4" target="_blank" >10.1007/s11103-018-0747-4</a>

Result language
angličtina
Original language name
An armadillo-domain protein participates in a telomerase interaction network
Original language description
The ARM protein interacts with both the N- and C-terminal domains of AtTERT in different cellular compartments. ARM interacts with CHR19 and TRF-like I family proteins that also bind AtTERT directly or through interaction with POT1a. The putative human ARM homolog co-precipitates telomerase activity and interacts with hTRF2 protein in vitro. Analysis of Arabidopsis arm mutants shows no obvious changes in telomere length or telomerase activity, suggesting that ARM is not essential for telomere maintenance. The observed interactions with telomerase and Myb-like domain proteins (TRF-like family I) may therefore reflect possible non-telomeric functions. Transcript levels of several DNA repair and ribosomal genes are affected in arm mutants, and ARM, likely in association with other proteins, suppressed expression of XRCC3 and RPSAA promoter constructs in luciferase reporter assays. In conclusion, ARM can participate in non-telomeric functions of telomerase, and can also perform its own telomerase-independent functions.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10611 - Plant sciences, botany

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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