Immunomodulatory effects of selected cyanobacterial peptides in vitro

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F18%3A00101600" target="_blank" >RIV/00216224:14310/18:00101600 - isvavai.cz</a>

Alternative codes found

RIV/61388971:_____/18:00491690

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0041010118301740" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0041010118301740</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.toxicon.2018.04.031" target="_blank" >10.1016/j.toxicon.2018.04.031</a>

Result language

angličtina

Original language name

Immunomodulatory effects of selected cyanobacterial peptides in vitro

Original language description

Cyanobacteria produce many biologically active metabolites synthesized via nonribosomal synthetic pathways such as cyclic microcystins (MCs) and linear aeruginosins (Aers). The present study aimed to investigate the effects of different MC variants and the newly isolated aerugenosin Aer-865 on macrophages, which represent one of the key effector cells within the innate immune responses. Specifically, our study included RAW 264.7 macrophage activation associated with production of cytotoxic and cytostatic nitric oxide (NO) as well as pro-inflammatory mediators like tumor necrosis factor alpha (TNF alpha) and interleukin 6 (IL-6). From the compounds investigated, commonly occurring MC variants (-RR,-YR) and Aer-865 had no significant effects within the non-cytotoxic concentrations tested, i.e. 0.001-1 mu M for MCs and 0.1-50 mu M for Aer-865. In contrast to known immunoactive MC-LR, the negligible immunomodulatory potential of tested MC congeners could be related to their differences in structure. The knowledge of MC structure-specific activities contributes to the understanding of complex toxicity of different MC variants and most importantly their mixtures. This study is one of the first study that evaluate the effect of larger set of cyanobacterial peptides on macrophages and compare their immunomodulatory potential.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Toxicon

ISSN

0041-0101

e-ISSN

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Volume of the periodical

149

Issue of the periodical within the volume

July

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

20-25

UT code for WoS article

000436917900003

EID of the result in the Scopus database

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