CalFitter: a web server for analysis of protein thermal denaturation data
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F18%3A00101753" target="_blank" >RIV/00216224:14310/18:00101753 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/18:00069362 RIV/00216305:26230/18:PU140099
Result on the web
<a href="http://dx.doi.org/10.1093/nar/gky358" target="_blank" >http://dx.doi.org/10.1093/nar/gky358</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/nar/gky358" target="_blank" >10.1093/nar/gky358</a>
Alternative languages
Result language
angličtina
Original language name
CalFitter: a web server for analysis of protein thermal denaturation data
Original language description
Despite significant advances in the understanding of protein structure-function relationships, revealing protein folding pathways still poses a challenge due to a limited number of relevant experimental tools. Widely-used experimental techniques, such as calorimetry or spectroscopy, critically depend on a proper data analysis. Currently, there are only separate data analysis tools available for each type of experiment with a limited model selection. To address this problem, we have developed the CalFitter web server to be a unified platform for comprehensive data fitting and analysis of protein thermal denaturation data. The server allows simultaneous global data fitting using any combination of input data types and offers 12 protein unfolding pathway models for selection, including irreversible transitions often missing from other tools. The data fitting produces optimal parameter values, their confidence intervals, and statistical information to define unfolding pathways. The server provides an interactive and easy-to-use interface that allows users to directly analyse input datasets and simulate modelled output based on the model parameters.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10102 - Applied mathematics
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nucleic Acids Research
ISSN
0305-1048
e-ISSN
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Volume of the periodical
46
Issue of the periodical within the volume
W1
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
„W344“-„W349“
UT code for WoS article
000438374100055
EID of the result in the Scopus database
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