CalFitter: a web server for analysis of protein thermal denaturation data

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26230%2F18%3APU140099" target="_blank" >RIV/00216305:26230/18:PU140099 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/18:00101753 RIV/00159816:_____/18:00069362
Result on the web
<a href="https://academic.oup.com/nar/article/46/W1/W344/4995690" target="_blank" >https://academic.oup.com/nar/article/46/W1/W344/4995690</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/nar/gky358" target="_blank" >10.1093/nar/gky358</a>

Result language
angličtina
Original language name
CalFitter: a web server for analysis of protein thermal denaturation data
Original language description
Despite significant advances in the understanding of protein structure-function relationships, revealing protein folding pathways still poses a challenge due to a limited number of relevant experimental tools. Widely-used experimental techniques, such as calorimetry or spectroscopy, critically depend on a proper data analysis. Currently, there are only separate data analysis tools available for each type of experiment with a limited model selection. To address this problem, we have developed the CalFitter web server to be a unified platform for comprehensive data fitting and analysis of protein thermal denaturation data. The server allows simultaneous global data fitting using any combination of input data types and offers twelve protein unfolding pathway models for selection, including irreversible transitions often missing from other tools. The data fitting produces optimal parameters, their confidence intervals, and statistical information to define unfolding pathways. The server provides an interactive and easy-to-use interface that allows users to directly analyse input datasets and simulate modelled output based on the model parameters. CalFitter web server is available free at https://loschmidt.chemi.muni.cz/calfitter/.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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