Trop-2 plasticity is controlled by epithelial-to-mesenchymal transition
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F18%3A00101762" target="_blank" >RIV/00216224:14310/18:00101762 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/18:00501686 RIV/00159816:_____/18:00070371 RIV/61989592:15110/18:73590821
Result on the web
<a href="https://academic.oup.com/carcin/article-abstract/39/11/1411/5054274?redirectedFrom=fulltext" target="_blank" >https://academic.oup.com/carcin/article-abstract/39/11/1411/5054274?redirectedFrom=fulltext</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/carcin/bgy095" target="_blank" >10.1093/carcin/bgy095</a>
Alternative languages
Result language
angličtina
Original language name
Trop-2 plasticity is controlled by epithelial-to-mesenchymal transition
Original language description
The cell surface glycoprotein Trop-2 is commonly overexpressed in carcinomas and represents an exceptional antigen for targeted therapy. Here, we provide evidence that surface Trop-2 expression is functionally connected with an epithelial phenotype in breast and prostate cell lines and in patient tumor samples. We further show that Trop-2 expression is suppressed epigenetically or through the action of epithelial-to-mesenchymal transition transcription factors and that deregulation of Trop-2 expression is linked with cancer progression and poor patient prognosis. Moreover, our data suggest that the cancer plasticity-driven intratumoral heterogeneity in Trop-2 expression may significantly contribute to response and resistance to therapies targeting Trop-2-expressing cells.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Carcinogenesis
ISSN
0143-3334
e-ISSN
1460-2180
Volume of the periodical
39
Issue of the periodical within the volume
11
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
1411-1418
UT code for WoS article
000456033800011
EID of the result in the Scopus database
2-s2.0-85058733516