Domino synthesis of quinazolin-4-yl thioureido alkanoates

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F18%3A00102110" target="_blank" >RIV/00216224:14310/18:00102110 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1007/s11696-017-0273-x" target="_blank" >https://doi.org/10.1007/s11696-017-0273-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11696-017-0273-x" target="_blank" >10.1007/s11696-017-0273-x</a>

Result language
angličtina
Original language name
Domino synthesis of quinazolin-4-yl thioureido alkanoates
Original language description
A simple convenient protocol for the synthesis of Me 2-[3-(2-(substituted phenyl)quinazolin-4-yl)thioureido] alkanoates I (R1 = H, CH3, OCH3; R2 = H, OCH3; R3 = H, CH3; R4 = H, CH3, CH2CH(CH3)2, C6H5; n = 0, 1, 2) has been described. It involves the domino reaction of various amino acid esters NH2CHR4(CH2)nC(O)OCH3·HCl with imidoylisothiocyanates II in Et acetate to afford quinazoline thiourea derivs. in excellent yields. Short reaction time, mild condition, simple work up, high yields, and pure products are the major advantages of this protocol. The no. of isolated pure compds. from this simple protocol is 24. The starting imidoyl isothiocyanates II were prepd. from the corresponding benzanilides III and purified by flash chromatog.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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