Ferrocenes as Potential Anticancer Drugs: Determination of The Mechanism of Action

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F18%3A00103342" target="_blank" >RIV/00216224:14310/18:00103342 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Ferrocenes as Potential Anticancer Drugs: Determination of The Mechanism of Action
Original language description
A series of ferrocene derivatives bearing either substituted or unsubstituted saturated five- and sixmembered nitrogen-containing heterocycles was synthesized. Some of these compounds showed clear cytotoxicity towards ovarian cancer cells in doses comparable to or even lower than Cisplatin, treatment of choice for ovarian cancer. The most promising ferrocene derivative was chosen to determine the mechanism of action inside SK-OV-3 cells. We used differential pulse voltammetry to measure low levels of accumulated drugs, which identified transferrin receptors as prominent transporters of ferrocenes. The important part of our work also consists in determining the mode of action consisting predominately in production of reactive oxygen species inside the cancer cells.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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