Ferrocenes as new anticancer drug candidates: Determination of the mechanism of action
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F20%3A00519357" target="_blank" >RIV/61388955:_____/20:00519357 - isvavai.cz</a>
Alternative codes found
RIV/67985858:_____/20:00519357 RIV/00209805:_____/20:00078278 RIV/00216224:14310/20:00115228
Result on the web
<a href="http://hdl.handle.net/11104/0304348" target="_blank" >http://hdl.handle.net/11104/0304348</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejphar.2019.172825" target="_blank" >10.1016/j.ejphar.2019.172825</a>
Alternative languages
Result language
angličtina
Original language name
Ferrocenes as new anticancer drug candidates: Determination of the mechanism of action
Original language description
Chemotherapy plays an essential role in the management of cancer worldwide. However, it is a non-specific treatment limited by major drawbacks, thus identification and testing of new promising molecular structures representing potential drug candidates are urgently needed. In this work, ferrocene complexes as potential antitumor drugs that display cytotoxicity in low micromolar concentrations against ovarian cancer cells A2780 and SK-OV-3 were investigated to identify their mode of action. Their mechanism of cellular accumulation was studied using differential pulse voltammetry and inductively coupled plasma mass spectrometry. Their mode of cell death induction was determined by changes in the mitochondrial membrane potential, production of reactive oxygen species and by Annexin V staining.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Pharmacology
ISSN
0014-2999
e-ISSN
—
Volume of the periodical
867
Issue of the periodical within the volume
JAN 2020
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
172825
UT code for WoS article
000504024800004
EID of the result in the Scopus database
2-s2.0-85075851969