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Ferrocenes as new anticancer drug candidates: Determination of the mechanism of action

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F20%3A00519357" target="_blank" >RIV/61388955:_____/20:00519357 - isvavai.cz</a>

  • Alternative codes found

    RIV/67985858:_____/20:00519357 RIV/00209805:_____/20:00078278 RIV/00216224:14310/20:00115228

  • Result on the web

    <a href="http://hdl.handle.net/11104/0304348" target="_blank" >http://hdl.handle.net/11104/0304348</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.ejphar.2019.172825" target="_blank" >10.1016/j.ejphar.2019.172825</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Ferrocenes as new anticancer drug candidates: Determination of the mechanism of action

  • Original language description

    Chemotherapy plays an essential role in the management of cancer worldwide. However, it is a non-specific treatment limited by major drawbacks, thus identification and testing of new promising molecular structures representing potential drug candidates are urgently needed. In this work, ferrocene complexes as potential antitumor drugs that display cytotoxicity in low micromolar concentrations against ovarian cancer cells A2780 and SK-OV-3 were investigated to identify their mode of action. Their mechanism of cellular accumulation was studied using differential pulse voltammetry and inductively coupled plasma mass spectrometry. Their mode of cell death induction was determined by changes in the mitochondrial membrane potential, production of reactive oxygen species and by Annexin V staining.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10403 - Physical chemistry

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    European Journal of Pharmacology

  • ISSN

    0014-2999

  • e-ISSN

  • Volume of the periodical

    867

  • Issue of the periodical within the volume

    JAN 2020

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    8

  • Pages from-to

    172825

  • UT code for WoS article

    000504024800004

  • EID of the result in the Scopus database

    2-s2.0-85075851969