Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F10%3A00349341" target="_blank" >RIV/86652036:_____/10:00349341 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger
Original language description
Mitochondria are emerging as idealized targets for anti-cancer drugs. Although they are inherent to all cells, drugs are being developed that selectively target the mitochondria of malignant cells without adversely affecting normal cells. Such anti-cancer drugs destabilizing mitochondria are referred to as mitocans, classified into several groups according to their mode of action and the location or nature of their specific targets. Many mitocans selectively interfere with the functions of cancer cell mitochondria, causing major disruptions often associated with overloads in ROS production leading to the induction of apoptosis. A common theme emerging is that mitochondrially mediated ROS activation as an apoptosis trigger offers a powerful basis for cancer therapy. Continued research is likely to identify increasing numbers of novel agents that should prove highly effective against a variety of cancers, circumventing tumor resistance to the other more established approaches
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular Aspects of Medicine
ISSN
0098-2997
e-ISSN
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Volume of the periodical
31
Issue of the periodical within the volume
1
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
31
Pages from-to
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UT code for WoS article
000276729700003
EID of the result in the Scopus database
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