The gut microbiome and aquatic toxicology: An emerging concept for environmental health
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F18%3A00106144" target="_blank" >RIV/00216224:14310/18:00106144 - isvavai.cz</a>
Result on the web
<a href="https://setac.onlinelibrary.wiley.com/doi/full/10.1002/etc.4249" target="_blank" >https://setac.onlinelibrary.wiley.com/doi/full/10.1002/etc.4249</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/etc.4249" target="_blank" >10.1002/etc.4249</a>
Alternative languages
Result language
angličtina
Original language name
The gut microbiome and aquatic toxicology: An emerging concept for environmental health
Original language description
The microbiome plays an essential role in the health and onset of diseases in all animals, including humans. The microbiome has emerged as a central theme in environmental toxicology because microbes interact with the host immune system in addition to its role in chemical detoxification. Pathophysiological changes in the gastrointestinal tissue caused by ingested chemicals and metabolites generated from microbial biodegradation can lead to systemic adverse effects. The present critical review dissects what we know about the impacts of environmental contaminants on the microbiome of aquatic species, with special emphasis on the gut microbiome. We highlight some of the known major gut epithelium proteins in vertebrate hosts that are targets for chemical perturbation, proteins that also directly cross-talk with the microbiome. These proteins may act as molecular initiators for altered gut function, and we propose a general framework for an adverse outcome pathway that considers gut dysbiosis as a major contributing factor to adverse apical endpoints. We present 2 case studies, nanomaterials and hydrocarbons, with special emphasis on the Deepwater Horizon oil spill, to illustrate how investigations into the microbiome can improve understanding of adverse outcomes. Lastly, we present strategies to functionally relate chemical-induced gut dysbiosis with adverse outcomes because this is required to demonstrate cause-effect relationships. Further investigations into the toxicant-microbiome relationship may prove to be a major breakthrough for improving animal and human health. Environ Toxicol Chem 2018;37:2758-2775.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10511 - Environmental sciences (social aspects to be 5.7)
Result continuities
Project
<a href="/en/project/LM2015051" target="_blank" >LM2015051: Research Centre for Toxic Compounds in the Environment</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Environmental Toxicology and Chemistry
ISSN
0730-7268
e-ISSN
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Volume of the periodical
37
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
18
Pages from-to
2758-2775
UT code for WoS article
000448832700002
EID of the result in the Scopus database
2-s2.0-85054496374