Metabolism of obeticholic acid in brown bullhead (Ameiurus nebulosus)
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F19%3A00110434" target="_blank" >RIV/00216224:14310/19:00110434 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007%2Fs11356-019-05398-2" target="_blank" >https://link.springer.com/article/10.1007%2Fs11356-019-05398-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11356-019-05398-2" target="_blank" >10.1007/s11356-019-05398-2</a>
Alternative languages
Result language
angličtina
Original language name
Metabolism of obeticholic acid in brown bullhead (Ameiurus nebulosus)
Original language description
Analysis of brown bullhead (Ameiurus nebulosus) bile by ultra performance liquid chromatography high-resolution mass spectrometry (UPLC/HRMS) revealed a series of bile acids similar to those found in humans. Accordingly, we chose this fish as a model organism to examine the metabolism of obeticholic acid, a bile acid used to treat a number of human liver diseases and the one that has the potential to occur as an environmental contaminant. The taurine and glycine conjugates of obeticholic acid and keto-obeticholic acid were identified, as well as the d-cysteinolic acid conjugate of obeticholic acid, likely a metabolite specific to fish. In addition, metabolites of obeticholic acid (sulphate and glucuronide) and several hydroxy-obeticholic acid derivatives were found, representing typical pathways of primary and secondary steroid metabolism. Brown bullhead exposed to obeticholic acid at a dose of 100 mg/kg gave no overt signs of distress or toxicity.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10511 - Environmental sciences (social aspects to be 5.7)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Environmental Science and Pollution Research
ISSN
0944-1344
e-ISSN
1614-7499
Volume of the periodical
26
Issue of the periodical within the volume
20
Country of publishing house
DE - GERMANY
Number of pages
9
Pages from-to
20316-20324
UT code for WoS article
000473172800025
EID of the result in the Scopus database
2-s2.0-85066044937