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Metabolism of obeticholic acid in brown bullhead (Ameiurus nebulosus)

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F19%3A00110434" target="_blank" >RIV/00216224:14310/19:00110434 - isvavai.cz</a>

  • Result on the web

    <a href="https://link.springer.com/article/10.1007%2Fs11356-019-05398-2" target="_blank" >https://link.springer.com/article/10.1007%2Fs11356-019-05398-2</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s11356-019-05398-2" target="_blank" >10.1007/s11356-019-05398-2</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Metabolism of obeticholic acid in brown bullhead (Ameiurus nebulosus)

  • Original language description

    Analysis of brown bullhead (Ameiurus nebulosus) bile by ultra performance liquid chromatography high-resolution mass spectrometry (UPLC/HRMS) revealed a series of bile acids similar to those found in humans. Accordingly, we chose this fish as a model organism to examine the metabolism of obeticholic acid, a bile acid used to treat a number of human liver diseases and the one that has the potential to occur as an environmental contaminant. The taurine and glycine conjugates of obeticholic acid and keto-obeticholic acid were identified, as well as the d-cysteinolic acid conjugate of obeticholic acid, likely a metabolite specific to fish. In addition, metabolites of obeticholic acid (sulphate and glucuronide) and several hydroxy-obeticholic acid derivatives were found, representing typical pathways of primary and secondary steroid metabolism. Brown bullhead exposed to obeticholic acid at a dose of 100 mg/kg gave no overt signs of distress or toxicity.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10511 - Environmental sciences (social aspects to be 5.7)

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Environmental Science and Pollution Research

  • ISSN

    0944-1344

  • e-ISSN

    1614-7499

  • Volume of the periodical

    26

  • Issue of the periodical within the volume

    20

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    9

  • Pages from-to

    20316-20324

  • UT code for WoS article

    000473172800025

  • EID of the result in the Scopus database

    2-s2.0-85066044937