Electrochemical detection of G-quadruplex by interaction with porphyrin ligand

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F19%3A00117630" target="_blank" >RIV/00216224:14310/19:00117630 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Electrochemical detection of G-quadruplex by interaction with porphyrin ligand
Original language description
Porphyrins are well-known binders of DNA and can also specifically target guanine quadruplexes (G4). Interaction of a selected porphyrin (Cu-TMPyPP) with oligonucleotide sequences either forming or not forming G4 was studied using cyclic voltammetry at hanging mercury drop electrode. The interaction is shown to be detectable by cyclic voltammetry as potential shift of a characteristic peak of Cu-TMPyPP which is observed for G4, single stranded as well as double stranded DNA. Nevertheless, further changes of this peak resulting from application of cyclic potential scans to the studied DNA before interaction with Cu-TMPyPP can be used to clearly distinguish G4 DNA, which can be applied as analytical tool for its detection.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
PROCEEDINGS OF THE 15TH INTERNATIONAL STUDENTS CONFERENCE MODERN ANALYTICAL CHEMISTRY
ISBN
9788074440687
ISSN
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e-ISSN
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Number of pages
5
Pages from-to
215-219
Publisher name
CHARLES UNIV, FAC SCIENCE
Place of publication
PRAGUE
Event location
Prague, CZECH REPUBLIC
Event date
Sep 19, 2019
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000576787700035

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