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Conducting composite films based on chitosan or sodium hyaluronate. Properties and cytocompatibility with human induced pluripotent stem cells

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F21%3A00118800" target="_blank" >RIV/00216224:14310/21:00118800 - isvavai.cz</a>

  • Alternative codes found

    RIV/61389013:_____/21:00533634 RIV/70883521:28110/21:63527460 RIV/70883521:28610/21:63527460 RIV/60461373:22810/21:43922595

  • Result on the web

    <a href="https://doi.org/10.1016/j.carbpol.2020.117244" target="_blank" >https://doi.org/10.1016/j.carbpol.2020.117244</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.carbpol.2020.117244" target="_blank" >10.1016/j.carbpol.2020.117244</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Conducting composite films based on chitosan or sodium hyaluronate. Properties and cytocompatibility with human induced pluripotent stem cells

  • Original language description

    Novel composite films combining biocompatible polysaccharides with conducting polyaniline (PANI) were prepared via the in-situ polymerization of aniline hydrochloride in the presence of sodium hyaluronate (SH) or chitosan (CH). The composite films possess very good cytocompatibility in terms of adhesion and proliferation of two lines of human induced pluripotent stem cells (hiPSC). Moreover, the cardiomyogenesis and even formation of beating clusters were successfully induced on the films. The proportion of formed cardiomyocytes demonstrated excellent properties of composites for tissue engineering of stimuli-responsive tissues. The testing also demonstrated antibacterial activity of the films against E. coli and PANI-SH was able to reduce bacterial growth from 2 x 10(5) to &lt; 1 cfu cm(-2). Physicochemical characterization revealed that the presence of polysaccharides did not notably influence conductivities of the composites being similar to 1 and similar to 2 S cm(-1) for PANI-SH and PANI-CH respectively; however, in comparison with neat PANI, it modified their topography making the films smoother with mean surface roughness of 4 (PANI-SH) and 14 nm (PANI-CH). The combination of conductivity, antibacterial activity and mainly cytocompatibility with hiPSC opens wide application potential of these polysaccharide-based composites.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10601 - Cell biology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Carbohydrate Polymers

  • ISSN

    0144-8617

  • e-ISSN

    1879-1344

  • Volume of the periodical

    253

  • Issue of the periodical within the volume

    February 2021

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    10

  • Pages from-to

    1-10

  • UT code for WoS article

    000596248700003

  • EID of the result in the Scopus database

    2-s2.0-85094181117