Analytical strategies for chemical exposomics: exploring limits and feasibility

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F21%3A00127852" target="_blank" >RIV/00216224:14310/21:00127852 - isvavai.cz</a>
Result on the web
<a href="https://academic.oup.com/exposome/article/1/1/osab003/6372691" target="_blank" >https://academic.oup.com/exposome/article/1/1/osab003/6372691</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/exposome/osab003" target="_blank" >10.1093/exposome/osab003</a>

Result language
angličtina
Original language name
Analytical strategies for chemical exposomics: exploring limits and feasibility
Original language description
Tackling the challenges of chemical exposomics will require the implementation of diverse analytical strategies and technological advancements. Herein, high-resolution mass spectrometry-based methods applied in current chemical exposome studies have been surveyed and are shown to be limited. Notably, liquid chromatography separations almost exclusively employ reversed-phase C18 columns using water/methanol gradients with formic acid additive, while gas chromatography is underexploited in the field at this stage. A systematic evaluation of strategies applied in related disciplines (i.e. metabolomics, proteomics, multiresidue trace analysis) was undertaken to provide practical guidance for the development of chemical exposomics. The approaches were assessed on the basis of their costs (i.e. capital expenditure, overhead and maintenance fees, expertise required, consumables) and potential benefits (i.e. improvements to sensitivity, coverage, reproducibility, throughput, ease of use) to prioritize those with promise for chemical exposomics application. Alongside a need for technological investments (e.g. advanced hardware updates), numerous low-cost strategies showed high potential benefits (e.g. different column phases, enhanced sample fractionation) and are feasible for rapid adoption.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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