Structure elucidation of multicolor emissive graphene quantum dots towards cell guidance
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F22%3A00119559" target="_blank" >RIV/00216224:14310/22:00119559 - isvavai.cz</a>
Alternative codes found
RIV/68081723:_____/22:00553531 RIV/00216305:26620/22:PU147301
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2022/QM/D1QM01126J" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2022/QM/D1QM01126J</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/d1qm01126j" target="_blank" >10.1039/d1qm01126j</a>
Alternative languages
Result language
angličtina
Original language name
Structure elucidation of multicolor emissive graphene quantum dots towards cell guidance
Original language description
Graphene quantum dots (GQDs) can become excellent bioimaging tools when tuned to emit at larger wavelengths due to the minimal tissue absorbance and emission in this range. Tuning the GQD structure can help but understanding the chemical structure responsible for their properties remains challenging. Herein, we elucidated the structure of GQDs synthesized from glucose and ammonium hydroxide using a fast microwave-assisted hydrothermal protocol. Remarkably, these GQDs exhibited emission from the NUV-Vis up to the NIR range. The structure and chemical composition were elucidated using advanced NMR techniques, such as two-dimensional nuclear magnetic resonance, combined with traditional spectroscopy and electron microscopy. The graphitic core composed of pyrazines presented localized defects and lower rotation mobility compared with their edges that were mainly formed by hydroxyl, acid, and amine functional groups, which paved the way for the observed multicolor red-shifted fluorescence emission. Confocal laser scanning microscopy revealed functional cell imaging in a wide spectral range of fluorescence from bright purple to red, confirming the uptake of GQDs by the cells without any observable toxicity. The non-cytotoxicity was further proved by the chemiluminescence cell viability adenosine triphosphate (ATP) assay. Combined with the tunable GQD emission, it gives them the potential to act as bioimaging carriers starting a new phase for their use in vivo.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10303 - Particles and field physics
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Materials Chemistry Frontiers
ISSN
2052-1537
e-ISSN
2052-1537
Volume of the periodical
6
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
145-154
UT code for WoS article
000730146400001
EID of the result in the Scopus database
2-s2.0-85123925022