The microbiological quality of bacteriophage product and its influence on antibacterial phage effect
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F23%3A00132456" target="_blank" >RIV/00216224:14310/23:00132456 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The microbiological quality of bacteriophage product and its influence on antibacterial phage effect
Original language description
Developing a drug form containing bacteriophages is an essential step of phage therapy implementation in practice. A crucial criterion of the final phage product is phage stability in variant conditions, in which applied phages could be exposed during manipulation with the product (i.e., contaminations by microorganisms and drug additives). This work concerns phage titer stability during exposition to preservatives, yeast, and mold. We assessed the stability of a myovirus against Pseudomonas aeruginosa and a myovirus against Staphylococcus aureus. These purified phages were inoculated by Candida albicans or Aspergillus niger and stored at room temperature in six variant preservatives, including organic acids salts and alcohols. After 24 hours, the titer of phages was determined by a standard drop test.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
30403 - Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])
Result continuities
Project
<a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů