Is environmental risk assessment possible with the alternatives to acute fish toxicity test? Case study with pharmaceuticals

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F24%3A00137792" target="_blank" >RIV/00216224:14310/24:00137792 - isvavai.cz</a>

Result on the web

<a href="https://enveurope.springeropen.com/articles/10.1186/s12302-024-01015-3" target="_blank" >https://enveurope.springeropen.com/articles/10.1186/s12302-024-01015-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12302-024-01015-3" target="_blank" >10.1186/s12302-024-01015-3</a>

Result language

angličtina

Original language name

Is environmental risk assessment possible with the alternatives to acute fish toxicity test? Case study with pharmaceuticals

Original language description

BackgroundAcute fish toxicity test (AFT) is one of the cornerstones of environmental risk assessment (ERA) of chemicals for the aquatic environment. Despite many efforts to find an alternative able to fully replace the test, there is still lasting pressure from stakeholders for AFT results.ResultsHere, we present the results of a case study with eight pharmaceuticals from various pharmaceutical groups with different levels of expected toxicity to fish. Selected compounds were tested in two validated alternative tests-fish embryo toxicity test with zebrafish (Danio rerio) (zFET) and in vitro RTgill-W1 assay according to their corresponding OECD guidelines TG 236 and TG 249, respectively. Data for AFT were collected from PubMed and ECOTOX knowledgebase databases, and acute toxicity to fish was further predicted in silico by the ECOSAR program. Predicted environmental risks (risk quotients, RQ, calculated using the exposure data from NORMAN) from both zFET and RTgill-W1 well correlated with the average RQs based on AFT LC50s. The strongest and most significant correlation was observed while comparing the AFT results with the median of combined alternative methods (zFET, RTgill-W1, ECOSAR).ConclusionsThis proposed approach combining experimental data with modeling could serve as a reliable tool for predictions of environmental risks promoting the 3R alternatives to acute fish toxicity testing.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10511 - Environmental sciences (social aspects to be 5.7)

Project

<a href="/en/project/EF17_043%2F0009632" target="_blank" >EF17_043/0009632: CETOCOEN Excellence</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Environmental Sciences Europe

ISSN

2190-4707

e-ISSN

2190-4715

Volume of the periodical

36

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

16

Pages from-to

1-16

UT code for WoS article

001350710400001

EID of the result in the Scopus database

2-s2.0-85208692766