Impact of the ONCOBIOME network in cancer microbiome research
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F25%3A00141584" target="_blank" >RIV/00216224:14310/25:00141584 - isvavai.cz</a>
Result on the web
<a href="https://www.nature.com/articles/s41591-025-03608-8" target="_blank" >https://www.nature.com/articles/s41591-025-03608-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41591-025-03608-8" target="_blank" >10.1038/s41591-025-03608-8</a>
Alternative languages
Result language
angličtina
Original language name
Impact of the ONCOBIOME network in cancer microbiome research
Original language description
The European Union-sponsored ONCOBIOME network has spurred an international effort to identify and validate relevant gut microbiota-related biomarkers in oncology, generating a unique and publicly available microbiome resource. ONCOBIOME explores the effects of the microbiota on gut permeability and metabolism as well as on antimicrobial and antitumor immune responses. Methods for the diagnosis of gut dysbiosis have been developed based on oncomicrobiome signatures associated with the diagnosis, prognosis and treatment responses in patients with cancer. The mechanisms explaining how dysbiosis compromises natural or therapy-induced immunosurveillance have been explored. Through its integrative approach of leveraging multiple cohorts across populations, cancer types and stages, ONCOBIOME has laid the theoretical and practical foundations for the recognition of microbiota alterations as a hallmark of cancer. ONCOBIOME has launched microbiota-centered interventions and lobbies in favor of official guidelines for avoiding diet-induced or iatrogenic (for example, antibiotic- or proton pump inhibitor-induced) dysbiosis. Here, we review the key advances of the ONCOBIOME network and discuss the progress toward translating these into oncology clinical practice.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature Medicine
ISSN
1078-8956
e-ISSN
1546-170X
Volume of the periodical
31
Issue of the periodical within the volume
4
Country of publishing house
DE - GERMANY
Number of pages
14
Pages from-to
1085-1098
UT code for WoS article
001464401800001
EID of the result in the Scopus database
2-s2.0-105002601807