Role of sigma signalling in mammalian myocardium

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F03%3A00009084" target="_blank" >RIV/00216224:14330/03:00009084 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Role of sigma signalling in mammalian myocardium
Original language description
Sigma receptors represent a group of enigmatic binding sites with many functions in different tissues. In rat heart, they are responsible for modulation of cardiac contractility. They are also responsible for some adverse side effects of certain psychotropic drugs on cardiovascular system. In this study, the effect of sigma receptor ligand haloperidol on guinea pig heart multicellular preparations was studied. Its positive inotropic effect previously described in rat cardiomyocytes was confirmed in leftatria and papillary muscles isolated from the right ventricles. Also desensitisation process previously reported in rat myocardium after repeated exposure to haloperidol was confirmed. The normalized course of mechanical restitution curve was not changed during perfusion with haloperidol. It is concluded that its positive inotropic effect is very likely mediated via increased cytosolic availability of calcium.
Czech name
—
Czech description
—

Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Chronobiological analysis in pathophysiology of cardiovascular system
ISBN
80-7013-394-5
ISSN
—
e-ISSN
—
Number of pages
7
Pages from-to
172
Publisher name
National Centre of Nursing and Other Health Professions and Masaryk University, Faculty of Medicine
Place of publication
Brno
Event location
Brno
Event date
Jan 1, 2003
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
—

Similar results(10)