The effect of sigma ligand haloperidol in guinea pig atrial preparation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F02%3A00005517" target="_blank" >RIV/00216224:14330/02:00005517 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The effect of sigma ligand haloperidol in guinea pig atrial preparation

Original language description

Sigma receptors ligands play a role in modulation of contractility in rat myocardium. The aim of the present study was to examine the effect of sigma ligand haloperidol in the multicellular guinea pig heart preparations. The effects of haloperidol on theamplitude of contraction and on the restitution of contractility were investigated. Marked positive inotropic effect previously described in rat cardiomyocytes (increase in the twitch amplitude ranging from 50 to 90 %, with maximal effect in the 5th minute of perfusion) was observed. The mechanical restitution pattern is not altered. Thus, the positive inotropic effect of sigma receptor ligand haloperidol was confirmed also in guinea pig atrial preparations. According to its effect on the mechanical restitution we can assume that it is mediated via increased cytoplasmatic Ca2+concentration.

Czech name

The effect of sigma ligand haloperidol in guinea pig atrial preparation

Czech description

Sigma receptors ligands play a role in modulation of contractility in rat myocardium. The aim of the present study was to examine the effect of sigma ligand haloperidol in the multicellular guinea pig heart preparations. The effects of haloperidol on theamplitude of contraction and on the restitution of contractility were investigated. Marked positive inotropic effect previously described in rat cardiomyocytes (increase in the twitch amplitude ranging from 50 to 90 %, with maximal effect in the 5th minute of perfusion) was observed. The mechanical restitution pattern is not altered. Thus, the positive inotropic effect of sigma receptor ligand haloperidol was confirmed also in guinea pig atrial preparations. According to its effect on the mechanical restitution we can assume that it is mediated via increased cytoplasmatic Ca2+concentration.

Type

D - Article in proceedings

CEP classification

ED - Physiology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2002

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

78. Physiological Days.

ISBN

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ISSN

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e-ISSN

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Number of pages

1

Pages from-to

56

Publisher name

ÚMFG SAV, Bratislava.

Place of publication

Piešťany, Slovak Republic.

Event location

5.-8.2.2002, Piešťany, Slovak Republic.

Event date

Jan 1, 2002

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

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