Desensitisation of sigma receptors in guinea pig atria

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F03%3A00008521" target="_blank" >RIV/00216224:14110/03:00008521 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Desensitisation of sigma receptors in guinea pig atria
Original language description
Previous studies have shown a modulatory effect of sigma receptor activation on cardiac contractility and its desensitisation. These experiments were performed in isolated rat ventricular myocytes. Since the rat myocardium is well known for a number of quite specific properties, this study was aimed at verifying the effects of sigma ligands in guinea pig atria. Isometric contractions were recorded in 19 adult male guinea pigs (stimulated at the rate of 1Hz). After 30-45 minutes of stabilisation haloperidol in 10nM concentration was added to the bath for 30 minutes. Then, a period of 15 min washout and another 30 min period of haloperidol perfusion followed. The changes of amplitude of contraction and of mechanical restitution were investigated. In allcases, marked positive inotropic effect was observed. The mechanical restitution pattern was not altered. This positive inotropic effect was attenuated after the second haloperidol administration which could indicate that sigma receptors
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Project
<a href="/en/project/GA102%2F01%2F1494" target="_blank" >GA102/01/1494: Optical recording of action potentials and its application in cardiology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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