Effect of sigma ligand haloperidol in guinea pig heart preparations

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F02%3A00006189" target="_blank" >RIV/00216224:14110/02:00006189 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Effect of sigma ligand haloperidol in guinea pig heart preparations

Original language description

The effects of sigma ligand haloperidol in the multicellular guinea pig heart preparations were examined. Adult male guinea pigs were used. Left atrium and papillary muscle from right ventricle were examined. The stimulated twiches in horizontal bath were recorded isometrically. Sigma ligand haloperidol (10nM) was administered for 30 minutes. Its effect on the amplitude of contraction and on the mechanical restitution was evaluated. Marked positive inotropic effect (increase in the twitch amplitude ranging from 50 to 90 % for atria and 5 to 45% for ventricles, with maximal effect in the 5th minute of ligand administration for both preparations) has been observed. The mechanical restitution pattern under the effect of sigma receptor ligand is not altered. Thus, the positive inotropic effect of haloperidol was confirmed in guinea pig heart preparations. According to its effect on the mechanical restitution can be assumed that it is mediated via increased cytoplasmatic calcium concentrati

Czech name

Effect of sigma ligand haloperidol in guinea pig heart preparations

Czech description

The effects of sigma ligand haloperidol in the multicellular guinea pig heart preparations were examined. Adult male guinea pigs were used. Left atrium and papillary muscle from right ventricle were examined. The stimulated twiches in horizontal bath were recorded isometrically. Sigma ligand haloperidol (10nM) was administered for 30 minutes. Its effect on the amplitude of contraction and on the mechanical restitution was evaluated. Marked positive inotropic effect (increase in the twitch amplitude ranging from 50 to 90 % for atria and 5 to 45% for ventricles, with maximal effect in the 5th minute of ligand administration for both preparations) has been observed. The mechanical restitution pattern under the effect of sigma receptor ligand is not altered. Thus, the positive inotropic effect of haloperidol was confirmed in guinea pig heart preparations. According to its effect on the mechanical restitution can be assumed that it is mediated via increased cytoplasmatic calcium concentrati

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2002

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Molecular and Cellular Cardiology

ISSN

0022-2828

e-ISSN

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Volume of the periodical

34

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

1

Pages from-to

"A87"

UT code for WoS article

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EID of the result in the Scopus database

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