Effect of sigma ligand haloperidol in guinea pig heart preparations.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F02%3A00006468" target="_blank" >RIV/00216224:14110/02:00006468 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Effect of sigma ligand haloperidol in guinea pig heart preparations.

Original language description

Our previous experiments with sigma receptor ligands in rat myocytes and isolated hearts revealed that these receptors play a role in modulation of contractility. The aim of this study was to examine the effect of sigma ligand haloperidol in the multicellular guinea pig heart preparations. Left atrium and papillary muscle from the right ventricle of 19 adult male guinea pigs were used. Stimulated twitches were recorded in horizontal perfusion baht in the isometrical mode. The effects of haloperidol on the amplitude of twitch and on the restitution of contractility were investigated. In all experiments, marked positive inotropic effect was observed. The mechanical restitution pattern under the effect of sigma receptor ligand was not altered. Thus, the positive inotropic effect of sigma receptor ligand haloperidol was confirmed also in guinea pig atrial and ventricular multicellular heart preparations. According to its effect on the mechanical restitution we can assume that it is mediate

Czech name

Effect of sigma ligand haloperidol in guinea pig heart preparations.

Czech description

Our previous experiments with sigma receptor ligands in rat myocytes and isolated hearts revealed that these receptors play a role in modulation of contractility. The aim of this study was to examine the effect of sigma ligand haloperidol in the multicellular guinea pig heart preparations. Left atrium and papillary muscle from the right ventricle of 19 adult male guinea pigs were used. Stimulated twitches were recorded in horizontal perfusion baht in the isometrical mode. The effects of haloperidol on the amplitude of twitch and on the restitution of contractility were investigated. In all experiments, marked positive inotropic effect was observed. The mechanical restitution pattern under the effect of sigma receptor ligand was not altered. Thus, the positive inotropic effect of sigma receptor ligand haloperidol was confirmed also in guinea pig atrial and ventricular multicellular heart preparations. According to its effect on the mechanical restitution we can assume that it is mediate

Type

D - Article in proceedings

CEP classification

ED - Physiology

OECD FORD branch

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Project

<a href="/en/project/GA102%2F01%2F1494" target="_blank" >GA102/01/1494: Optical recording of action potentials and its application in cardiology</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2002

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

New Frontiers in Basic Cardiovascular Research.

ISBN

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ISSN

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e-ISSN

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Number of pages

1

Pages from-to

44

Publisher name

ÚMFG SAV

Place of publication

Bratislava

Event location

4.-7.10.2002, Smolenice, Slovak Republic

Event date

Jan 1, 2002

Type of event by nationality

EUR - Evropská akce

UT code for WoS article

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