Detailed studies of the human genome 3D structure

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F03%3A00009644" target="_blank" >RIV/00216224:14330/03:00009644 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Detailed studies of the human genome 3D structure
Original language description
The structure of chromosome territory 17 in interphase nuclei was investigated using 3D FISH and 5 DNA probes. 3D positions of the corresponding signals were determined for approximately 30-40 nuclei of Go and stimulated lymphocytes. Individual territories were then superimposed one over another in such a way that signals of the same probe were as close together as possible. The results were compared with those obtained from randomly generated points in 3D space. Optimal positioning of chromosome territories showed for the first time non-random 3D structure of interphase chromosome. It is pointed out that new mathematical methods for the investigation of the chromosome structure in interphase nuclei are needed.
Czech name
Detailní studie 3D struktury lidského genomu
Czech description
Detailní studie 3D struktury lidského genomu.

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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