Realtionship betwen K-ras mutation and the expression of p21 WAF1/CIP1 and p53 in chronic pankreatitis and pancreatic adenocarcinoma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F03%3A00012154" target="_blank" >RIV/00216224:14330/03:00012154 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Realtionship betwen K-ras mutation and the expression of p21 WAF1/CIP1 and p53 in chronic pankreatitis and pancreatic adenocarcinoma

Original language description

Overexpression of p21WAF1/CIP1wasrecently discribed as an early event in the development of pancreatic intraepihelial neoplasia. Since activating K-ras mutation are described in more than 80% of pancreatic cancers and are known to increase intracellularlevels of p21WAF1/CIP1 in experimental models, the posible role of activating K-ras mutations in an induction of the p21WAF1/CIP1 expression was investigated in our study.

Czech name

Realtionship betwen K-ras mutation and the expression of p21 WAF1/CIP1 and p53 in chronic pankreatitis and pancreatic adenocarcinoma

Czech description

Overexpression of p21WAF1/CIP1wasrecently discribed as an early event in the development of pancreatic intraepihelial neoplasia. Since activating K-ras mutation are described in more than 80% of pancreatic cancers and are known to increase intracellularlevels of p21WAF1/CIP1 in experimental models, the posible role of activating K-ras mutations in an induction of the p21WAF1/CIP1 expression was investigated in our study.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

<a href="/en/project/NK6153" target="_blank" >NK6153: Risk of pancreatic karcinoma in patients with chronic pancreatitis</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2003

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neoplasma

ISSN

0028-2685

e-ISSN

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Volume of the periodical

50

Issue of the periodical within the volume

5

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

319-325

UT code for WoS article

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EID of the result in the Scopus database

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