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Protein and its Function Based on a Subcellular Localization
Protein p21(Cip1/Waf1) is a cyclin-dependent kinase inhibitor, which target of p53 protein. Based on the localization, p21(Cip1/Waf1) protein executes various functionsin the cell. In the nucleus ...
CE - Biochemie
- 2011 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
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Overexpression of p21(WAF1/CIP1) in the development of pancreatic intraepithelial neoplasms and the relationship to the p53, HER-2/neu and K-ras status
Overexpression of p21(WAF1/CIP1) is an early event in the development of PanIN and the possible role of activating K-ras mutations and HER-2/neu overexpression in the induction of p21(WAF1/CIP1)ex...
FD - Onkologie a hematologie
- 2004 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Cell cycle inhibitor p21/WAF1/CIP1 as a cofactor of MITF expression in melanoma cells.
p21/WAF1/Cip1 (p21), a cyclin dependent kinase inhibitor, may act as an antioncogene, but may also behave as a tumor promoting factor by inhibiting apoptosis. Here we show that the p21 protein positively r...
FD - Onkologie a hematologie
- 2010 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
A role for p21 (WAF1) in the cAMP-dependent differentiation of F9 teratocarcinoma cells into parietal endoderm.
endoderm. We show that the levels of cyclin-dependent kinase inhibitor p21/WAF1/Cip1 (p21) protein and mRNA are dramatically elevated at the end of this differentiation, concomitantly with the appearance of p2...
FD - Onkologie a hematologie
- 2005 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Amplification and overexpression of HER-2/neu in invasive ductal carcinomas of the pancreas and pancreatic intraepithelial neoplasms and the relationship to the expression of p21(WAF1/CIP1)
Overexpression of p21(WAF1/CIP1)seems to be HER-2/neu independent based on our results. Expression of HER-2/neu is growing according to grade of the ductal lesion and overexpression of HER-2/neu was demonstrated in 18% carc...
FD - Onkologie a hematologie
- 2004 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Realtionship betwen K-ras mutation and the expression of p21 WAF1/CIP1 and p53 in chronic pankreatitis and pancreatic adenocarcinoma
intracellularlevels of p21WAF1/CIP1 in experimental models, the posible role of activating K-ras mutations in an induction of the p21WAF1/CIP1 expression was investigated in our study....
FE - Ostatní obory vnitřního lékařství
- 2003 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Effect of TGF--, inhibitors of mitogen-activated protein kinases and proteasome inhibitor on TGF-- receptors mRNAs, Smad mRNAs and target protein Smad mRNAs and target protein p21/CIP1/WAF1 mRNA
Exogenous TGF- -1 reduced Smad 1-5 mRNA levels and also reduced TGF-- receptors mRNA levels in human leukemia cell line CTV-1 established from a patient with relapsed acute monoblastic leukemia and bought from the DSMZ-German Collection of Microorgan...
FD - Onkologie a hematologie
- 2004 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Exposure to fractionated dose of 60 Gy affects molecular response of HL-60 cells to irradiation
independent increase in p21(WAF1/Cip1), and not by activation of checkpoint kinase Chk-2...
FD - Onkologie a hematologie
- 2010 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Haemanthamine alters sodium butyrate-induced histone acetylation, p21(WAF1/Cip1) expression, Chk1 and Chk2 activation and leads to increased growth inhibition and death in A2780 ovarian cancer cells
of proteins regulating the cell cycle. Notably, p21(WAF1/Cip1) was upregulated in both and downregulated p21(WAF1/Cip1) in both tested cell lines. The sensitization of cells to HA......
Pharmacology and pharmacy
- 2017 •
- Jimp •
- Link
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Jimp - Článek v periodiku v databázi Web of Science
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MicroRNAs Regulate p21(Waf1/Cip1) Protein Expression and the DNA Damage Response in Human Embryonic Stem Cells
the nonfunctional p53-p21 axis of the G1/S checkpoint pathway with subsequent relevance for cell cycle regulation and the DNA damage response (DDR). Importantly, p21 mRNA is clearly presentand upregulated after the DDR in hESCs, bu...
EE - Mikrobiologie, virologie
- 2012 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
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