Gene expression in colorectal carcinoma determined by cDNA microarrays using a combination of several evaluation approaches.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F04%3A00009700" target="_blank" >RIV/00216224:14330/04:00009700 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/04:00108488

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Gene expression in colorectal carcinoma determined by cDNA microarrays using a combination of several evaluation approaches.

Original language description

We have compared colorectal carcinoma tissues with parallel samples of epithelial tissue and identified, by means of Human 1.7K cDNA microarrays, a set of genes with significantly altered expression in 12 patients. We used a combination of several approaches of microarray data analysis to be sure that the results were reliable. Although we have found differences between the results obtained by various image analysis software packages and using different statistical tools, we have identified the group of22 genes with significantly altered expression in colorectal carcinoma tissue as compared with epithelial tissue using all evaluation approaches. Hierarchical clustering showed the possibility of dividing the patients into two groups according to the presence of metastases in regional lymph nodes. We have proposed 6 genes as potential markers for the detection of the presence of regional metastases in patients. We suppose that the proposed advance in the analysis of microarray data coul

Czech name

Exprese genů u kolorektálního karcinomu určená pomocí cDNA mikročipů užitím kombinace několika vyhodnocovacích postupů

Czech description

Exprese genů u kolorektálního karcinomu určená pomocí cDNA mikročipů užitím kombinace několika vyhodnocovacích postupů.

Type

D - Article in proceedings

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2004

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Biophysics of the Genome

ISBN

80-210-3560-9

ISSN

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e-ISSN

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Number of pages

9

Pages from-to

29-37

Publisher name

Masaryk University

Place of publication

Brno

Event location

Brno

Event date

Oct 12, 2004

Type of event by nationality

EUR - Evropská akce

UT code for WoS article

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