Cytological study of DNA methylation and histone methylation patterns in human cell lines
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F04%3A00009706" target="_blank" >RIV/00216224:14330/04:00009706 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/04:00108490
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Cytological study of DNA methylation and histone methylation patterns in human cell lines
Original language description
Epigenetic processes are defined as heritable changes in genome function that occur without a change in DNA sequence. Gene expression, chromosome segregation, DNA replication, repair, and recombination all act, not on DNA alone, but on the chromatin template. DNA methylation, along with histone lysine methylation, establishes the framework for long-term epigenetic maintenance. The discovery that enzymes can (re)organise chromatin into accessible and inaccessible configurations revealed epigenetic mechanisms that considerably extend the information potential of the genetic code. In mammals, heterochromatin is characterised by DNA methylation at CpG dinucleotides and methylation at lysine 9 of histone 3 (H3- K9), whereas euchromatin is associated with methylation at lysine 4 of histone 3 (H3-K4). In our experiments, the detection of DNA methylated regions at chromosomal level was performed using indirect immunofluorescence technique combined with FISH. The selected metaphase chromosomes
Czech name
Cytologická studie chování DNA metylace a histonové metylace v lidských buněčných liniích
Czech description
Cytologická studie chování DNA metylace a histonové metylace v lidských buněčných liniích.
Classification
Type
D - Article in proceedings
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Biophysics of the Genome
ISBN
80-210-3560-9
ISSN
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e-ISSN
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Number of pages
4
Pages from-to
72-75
Publisher name
Masaryk University
Place of publication
Brno
Event location
Brno
Event date
Oct 12, 2004
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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