Histone H3 lysine 4 methylation signature associated with human undernutrition
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F18%3APU129931" target="_blank" >RIV/00216305:26220/18:PU129931 - isvavai.cz</a>
Result on the web
<a href="http://www.pnas.org/content/115/48/E11264" target="_blank" >http://www.pnas.org/content/115/48/E11264</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1073/pnas.1722125115" target="_blank" >10.1073/pnas.1722125115</a>
Alternative languages
Result language
angličtina
Original language name
Histone H3 lysine 4 methylation signature associated with human undernutrition
Original language description
Chronically undernourished children become stunted during their first 2 years and thereafter bear burdens of ill health for the rest of their lives. Contributors to stunting include poor nutrition and exposure to pathogens, and parental history may also play a role. However, the epigenetic impact of a poor environment on young children is largely unknown. Here we show the unfolding pattern of histone H3 lysine 4 trimethylation (H3K4me3) in children and mothers living in an urban slum in Dhaka, Bangladesh. A pattern of chromatin modification in blood cells of stunted children emerges over time and involves a global decrease in methylation at canonical locations near gene start sites and increased methylation at ectopic sites throughout the genome. This redistribution occurs at metabolic and immune genes and was specific for H3K4me3, as it was not observed for histone H3 lysine 27 acetylation in the same samples. Methylation changes in stunting globally resemble changes that occur in vitro in response to altered methylation capacity, suggesting that reduced levels of one-carbon nutrients in the diet play a key role in stunting in this population. A network of differentially expressed genes in stunted children reveals effects on chromatin modification machinery, including turnover of H3K4me3, as well as posttranscriptional gene regulation affecting immune response pathways and lipid metabolism. Consistent with these changes, reduced expression of the endocytic receptor gene LDL receptor 1 (LRP1) is a driver of s
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN
0027-8424
e-ISSN
1091-6490
Volume of the periodical
115
Issue of the periodical within the volume
48
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
„E11264“-„E11273“
UT code for WoS article
000451351000013
EID of the result in the Scopus database
2-s2.0-85057293442