Methylation of histones in myeloid leukemias as a potential marker of granulocyte abnormalities

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F05%3A00012357" target="_blank" >RIV/00216224:14330/05:00012357 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/05:00001090

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Methylation of histones in myeloid leukemias as a potential marker of granulocyte abnormalities

Original language description

We show that common heterochromatin antigenic protein markers [HP1alpha, -betta, -gamma and mono-, di-, and trimethylated histone H3 lysine 9 (H3K9)], although present in human blood progenitor CD34+ cells, differentiated lymphocytes, and monocytes, areabsent in neutrophil granulocytes and to large extent, in eosinophils. Monomethylated and in particular, dimethylated H3K9 are present to variable degrees in the granulocytes of chronic myeloid leukemia (CML) patients, without being accompanied by HP1 proteins. In patients with an acute phase of CML and in acute myeloid leukemia patients, strong methylation of H3K9 and all isoforms of HP1 are detected. In chronic forms of CML, no strong correlations among the level of histone methylation, disease progression, and modality of treatment were observed. Histone methylation was found even in "cured" patients without Philadelphia chromosome (Ph) resulting from +(9;22)(q34;q11) BCR/ABL translocation, suggesting an incomplete process of develop

Czech name

Metylace histonů u myeloidních leukémií jako potenciální znak abnormality granulocytů

Czech description

Metylace histonů u myeloidních leukémií jako potenciální znak abnormality granulocytů.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2005

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Leukocyte Biology

ISSN

0741-5400

e-ISSN

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Volume of the periodical

77

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

100-111

UT code for WoS article

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EID of the result in the Scopus database

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