Methylation of histone H3K9 in human blood cells and in granulocytes of patients with myeloid leukemia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F04%3A00009703" target="_blank" >RIV/00216224:14330/04:00009703 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/04:00108436

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Methylation of histone H3K9 in human blood cells and in granulocytes of patients with myeloid leukemia

Original language description

We show that common heterochromatin antigenic protein markers (HP1alpha, beta, gamma, mono-, di-, and tri-methylated histone H3K9), while present in human blood progenitor CD34+ cells, differentiated lymphocytes and monocytes, are absent in neutrophile granulocytes and, to large extent, in eosinophiles. Mono-methylated and, in particular, di-methylated H3K9 are present to variable degrees in the granulocytes of CML patients, without being accompanied by HP1 proteins. In patients with an acute phase of CML and in AML patients, strong methylation of H3K9 and all isoformes of HP1 are detected. In chronic forms of CML, no strong correlations among the level of histone methylation, disease progression and modality of treatment were observed. Histone methylation was found even in cured patients without BCR/ABL translocation, suggesting an incomplete process of developmentally-regulated chromatin remodeling in the granulocytes of these patients. Similarly, reprogramming of leukemia HL-60 cell

Czech name

Metylace histonu H3K9 v lidských krevních buňkách a v granulocytech pacientů s myeloidní leukémií

Czech description

Metylace histonu H3K9 v lidských krevních buňkách a v granulocytech pacientů s myeloidní leukémií.

Type

D - Article in proceedings

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2004

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Biophysics of the Genome

ISBN

80-210-3560-9

ISSN

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e-ISSN

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Number of pages

5

Pages from-to

53-57

Publisher name

Masaryk University

Place of publication

Brno

Event location

Brno

Event date

Oct 12, 2004

Type of event by nationality

EUR - Evropská akce

UT code for WoS article

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