Relationship of HP1 proteins to centromeric heterochromatin characterized by the presence of H3(K9) and absence of H3(K4) dimethylation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F04%3A00009710" target="_blank" >RIV/00216224:14330/04:00009710 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Relationship of HP1 proteins to centromeric heterochromatin characterized by the presence of H3(K9) and absence of H3(K4) dimethylation

Original language description

Recent studies have highlighted the importance of heterochromatin proteins HP1 (alpha,beta,gamma) in the nuclear structure organization. Patterns and levels of HP1 proteins and their relationship to specific histone methylations are associated with bothheterochromatic and euchromatic loci. In this study we have examined arrangement of HP1 proteins and histone modifications related to the centromeric heterochromatin of human and mouse chromosomes. Focal arrangement of HP1beta was characterized by a smaller foci located closer to the nuclear periphery and larger foci associated with the nucleoli of human colon adenocarcinoma HT29 cells. Heterochromatin of selected centromeres (9cen,14/22cen,Ycen) co-localized with foci of HP1beta. Immuno-FISH analyses revealed that centromeres analyzed were H3(K9) dimethylated and absent of H3(K4) dimethylation studied in HT29 cells and in human small lung carcinoma cells A549. Chromatin immunoprecipitation analyses (ChIPs) determined the same histone m

Czech name

Vztah mezi HP1 proteiny a centromerickým heterochromatinem charakterizovaný přítomností H3(K9) a absencí H3(K4) dimetylace

Czech description

Vztah mezi HP1 proteiny a centromerickým heterochromatinem charakterizovaný přítomností H3(K9) a absencí H3(K4) dimetylace

Type

D - Article in proceedings

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2004

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Biophysics of the Genome

ISBN

80-210-3560-9

ISSN

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e-ISSN

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Number of pages

7

Pages from-to

1-7

Publisher name

Masaryk University

Place of publication

Brno

Event location

Brno, Czech Republic

Event date

Oct 12, 2004

Type of event by nationality

EUR - Evropská akce

UT code for WoS article

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