Nuclear levels and patterns of histone H3 modification and HP1 proteins after inhibition of histone deacetylases

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F05%3A00012958" target="_blank" >RIV/00216224:14330/05:00012958 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/05:00023712 RIV/00216208:11130/05:2970
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Nuclear levels and patterns of histone H3 modification and HP1 proteins after inhibition of histone deacetylases
Original language description
The effects of the histone deacetylase inhibitors (HDACi) trichostatin A (TSA) and sodium butyrate (NaBt) were studied in A549, HT29 and FHC human cell lines. Global histone hyperacetylation, leading to decondensation of interphase chromatin, was characterized by an increase in H3(K9) and H3(K4) dimethylation and H3(K9) acetylation. The levels of all isoforms of heterochromatin protein, HP1, were reduced after HDAC inhibition. The observed changes in the protein levels were accompanied by changes in their interphase patterns. In control cells, H3(K9) acetylation and H3(K4) dimethylation were substantially reduced to a thin layer at the nuclear periphery, whereas TSA and NaBt caused the peripheral regions to become intensely acetylated at H3(K9) and dimethylated at H3(K4). The dispersed pattern of H3(K9) dimethylation was stable even at the nuclear periphery of HDACi-treated cells. After TSA and NaBt treatment, the HP1 proteins were repositioned more internally in the nucleus, being clo
Czech name
Jaderné úrovně a vzory modifikací histonů H3 a proteinů HP1 po potlačení deacetyláz histonů
Czech description
Byly studovány jaderné úrovně a vzory modifikací histonů H3 a proteinů HP1 po potlačení deacetyláz histonů.

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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