SUV39h-independent association of HP1b with fibrillarin-positive nucleolar regions

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F10%3A00051235" target="_blank" >RIV/00216224:14330/10:00051235 - isvavai.cz</a>

Result on the web

<a href="http://www.springerlink.com/content/03353h53h300j70k/" target="_blank" >http://www.springerlink.com/content/03353h53h300j70k/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00412-009-0252-2" target="_blank" >10.1007/s00412-009-0252-2</a>

Result language

angličtina

Original language name

SUV39h-independent association of HP1b with fibrillarin-positive nucleolar regions

Original language description

Heterochromatin protein 1 (HP1), which binds to sites of histone H3 lysine 9 (H3K9) methylation, is primarily responsible for gene silencing and the formation of heterochromatin. We observed that HP1beta is located in both the chromocenters and fibrillarin-positive nucleoli interiors. However, HP1alfa and HP1gamma occupied fibrillarin-positive compartments to a lesser extent, corresponding to the distinct levels of HP1 subtypes at the promoter of rDNA genes. Deficiency of histone methyltransferases SUV39h, and/or inhibition of histone deacetylases (HDACi) decreased HP1beta and H3K9 trimethylation at chromocenters, but not in fibrillarin-positive regions that co-localized with RNA Pol I. Similarly, SUV39h- and HDACi-dependent nucleolar rearrangement andinhibition of rDNA transcription did not affect the association between HP1beta - and fibrillarin. The presence of HP1beta in nucleoli is likely connected with transcription of ribosomal genes and with the role of fibrillarin in nucleola

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chromosoma

ISSN

0009-5915

e-ISSN

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Volume of the periodical

119

Issue of the periodical within the volume

3

Country of publishing house

DE - GERMANY

Number of pages

15

Pages from-to

227-241

UT code for WoS article

000277786400001

EID of the result in the Scopus database

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