A Two-Phase Segmentation of Cell Nuclei Using Fast Level Set-Like Algorithms

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F09%3A00034316" target="_blank" >RIV/00216224:14330/09:00034316 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14330/09:00067108
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
A Two-Phase Segmentation of Cell Nuclei Using Fast Level Set-Like Algorithms
Original language description
An accurate localization of a cell nucleus boundary is inevitable for any further quantitative analysis of various subnuclear structures within the cell nucleus. In this paper, we present a novel approach to the cell nucleus segmentation in fluorescencemicroscope images exploiting the level set framework. The proposed method works in two phases. In the first phase, the image foreground is separated from the background using a fast level set-like algorithm by Nilsson and Heyden (2003). A binary mask ofisolated cell nuclei as well as their clusters is obtained as a result of the first phase. A fast topology-preserving level set-like algorithm by Maška and Matula (2008) is applied in the second phase to delineate individual cell nuclei within the clusters. The potential of the new method is demonstrated on images of DAPI-stained nuclei of a lung cancer cell line A549 and promyelocytic leukemia cell line HL60.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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