Real-time visualization of protein empty space with varying parameters

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F13%3A00065959" target="_blank" >RIV/00216224:14330/13:00065959 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Real-time visualization of protein empty space with varying parameters
Original language description
Exploration of empty space inside protein structures is playing a crucial role in protein engineering and drug design. Such empty space inside protein can be utilized for design of protein mutations. The importance of empty space is also based on its ability to accept a small ligand molecule which can react with the protein. The product of such reaction can form a basis of new medications. Many algorithms enabling computation of these empty spaces, often marked as voids, have been published and their results were evaluated by protein engineers to confirm their chemical relevance. However, not each void of the protein can be considered as a target point of ligand binding. Thus the following examination and assessment of all voids has to be performed. Inthis phase the visual representation of voids is very valuable and substantially decreases time of this evaluation phase. In this paper, we introduce a novel algorithm for visualization and further evaluation of voids in real-time.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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