Driven hematopoietic differentiation of embryonic stem cells: Epigenetic perspectives
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F14%3A00073400" target="_blank" >RIV/00216224:14330/14:00073400 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.2174/13816128113199990524" target="_blank" >http://dx.doi.org/10.2174/13816128113199990524</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/13816128113199990524" target="_blank" >10.2174/13816128113199990524</a>
Alternative languages
Result language
angličtina
Original language name
Driven hematopoietic differentiation of embryonic stem cells: Epigenetic perspectives
Original language description
Hematopoietic progenitors derived from human embryonic stem cells (hESCs) present both a potential cell source for cell-replacement therapies and an in vitro model for hematopoietic stem cell (HSC) development. Current protocols for the hematopoietic differentiation of hESCs suffer from low efficiency and functional defects in the derived HSCs. Epigenetic mechanisms of HSC development should be addressed to overcome these imperfections. The focus of this review is to summarize the knowledge on the epigenetic regulation of pluripotency and lineage-specific genes with the emphasis on the hematopoietic cell lineage. The potential utilization of this knowledge to improve the generation of HSCs for clinical application is also discussed.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GBP302%2F12%2FG157" target="_blank" >GBP302/12/G157: Dynamics and Organization of Chromosomes in the Cell Cycle and during Differentiation under Normal and Pathological Conditions</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
CURRENT PHARMACEUTICAL DESIGN
ISSN
1381-6128
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
11
Country of publishing house
AE - UNITED ARAB EMIRATES
Number of pages
13
Pages from-to
1674-1686
UT code for WoS article
000334311500011
EID of the result in the Scopus database
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