Biodistribution of non-coated gamma-Fe2O3 nanoparticles in stem cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F15%3A00081086" target="_blank" >RIV/00216224:14330/15:00081086 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Biodistribution of non-coated gamma-Fe2O3 nanoparticles in stem cells
Original language description
Superparamagnetic iron oxide nanoparticles have become a useful tool in biomedicine. Their applications include cell labelling for magnetic resonance imaging, drug and gene delivery and cell targeting. Targeting cells to a specific location is a first step in development of regenerative cellular therapy. To provide optimal dispersion, increase nanoparticle intake and minimize toxic effects Fe2O3 nanoparticles are often coated with different types of organic materials including citrate, dextran, albumin,starch polyethylene glycol or dimercaptosuccinic acid. However, magnetism of the nanoparticles decreases with diameter of the coating. Recently, the gamma-Fe2O3 nanoparticles were synthesized in gas phase by microwave plasma torch without any surfactants and additives. Therefore, this technology can open new perspectives for bioapplications. We studied interaction of different cell cultures including pluripotent cells with microwave-torch gamma-e2O3 nanoparticles.
Czech name
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Czech description
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Project
<a href="/en/project/GBP302%2F12%2FG157" target="_blank" >GBP302/12/G157: Dynamics and Organization of Chromosomes in the Cell Cycle and during Differentiation under Normal and Pathological Conditions</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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