YEAST: AN APPROPRIATE MODEL FOR THE DETECTION OF CANCEROSTATICS

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14410%2F09%3A00035552" target="_blank" >RIV/00216224:14410/09:00035552 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

YEAST: AN APPROPRIATE MODEL FOR THE DETECTION OF CANCEROSTATICS

Original language description

Three selected yeast strains of Yarrowia lipolytica species were used as modelling objects to test 62 chemical substances considered to be potentional cytostatics. In the cells following phenomena were observed and analysed: 1/ process of cell cycle, 2/process of mitosis, 3/ morphology of nucleus, formation of polynuclear forms, 3/ amount of DNA in nucleus, polyploid nuclei formation, 4/ localization, morphology of microtubular cytoskeleton, 5/ amount and localization of actin microfilaments, 6/ presence, amount and localization of calmodulin. Six of all analysed substances were found to be appropriate (as cytostatics) and were suggested for a further detailed analysis.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

37th Annual Conference on Yeasts.

ISBN

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ISSN

1336-4839

e-ISSN

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Number of pages

80

Pages from-to

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Publisher name

Chemický ústav SAV Bratislava

Place of publication

Slovensko

Event location

Kongresové centrum SAV

Event date

May 13, 2009

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

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