The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F11%3A00050490" target="_blank" >RIV/00216224:14740/11:00050490 - isvavai.cz</a>
Alternative codes found
RIV/00027162:_____/11:#0000953
Result on the web
<a href="http://www.genesdev.org/cgi/doi/10.1101/gad.16962311" target="_blank" >http://www.genesdev.org/cgi/doi/10.1101/gad.16962311</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1101/gad.16962311" target="_blank" >10.1101/gad.16962311</a>
Alternative languages
Result language
angličtina
Original language name
The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes
Original language description
Various cyclin-dependent kinase (Cdk) complexes have been implicated in the regulation of transcription. In this study, we identified a 70-kDa Cyclin K (CycK) that binds Cdk12 and Cdk13 to form two different complexes (CycK/Cdk12 or CycK/Cdk13) in humancells. The CycK/Cdk12 complex regulates phosphorylation of Ser2 in the C-terminal domain of RNA polymerase II and expression of a small subset of human genes, as revealed in expression microarrays. Depletion of CycK/Cdk12 results in decreased expressionof predominantly long genes with high numbers of exons. The most prominent group of down-regulated genes are the DNA damage response genes, including the critical regulators of genomic stability: BRCA1 (breast and ovarian cancer type 1 susceptibility protein 1), ATR (ataxia telangiectasia and Rad3-related), FANCI, and FANCD2. We show that CycK/Cdk12, rather than CycK/Cdk13, is necessary for their expression.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP305%2F11%2F1564" target="_blank" >GAP305/11/1564: The novel isoform of cyclin K is a partner of cdk12 kinase regulating eukaryotic transcription and alternative splicing</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Genes & Development
ISSN
0890-9369
e-ISSN
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Volume of the periodical
25
Issue of the periodical within the volume
20
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
2158-2172
UT code for WoS article
000296496100005
EID of the result in the Scopus database
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