Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F11%3A00052845" target="_blank" >RIV/00216224:14740/11:00052845 - isvavai.cz</a>
Alternative codes found
RIV/61389030:_____/11:00367668 RIV/60460709:41610/11:51937 RIV/62157124:16370/11:43870290
Result on the web
<a href="http://dx.doi.org/10.1021/np100638h" target="_blank" >http://dx.doi.org/10.1021/np100638h</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/np100638h" target="_blank" >10.1021/np100638h</a>

Result language
angličtina
Original language name
Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro
Original language description
Cudraflavone B (1) is a prenylated flavonoid found in large amounts in the roots of Morus alba, a plant used as a herbal remedy for its reputed anti-inflammatory properties. The present study shows that this compound causes a significant inhibition of inflammatory mediators in selected in vitro models. Thus, 1 was identified as a potent inhibitor of tumor necrosis factor R (TNFR) gene expression and secretion by blocking the translocation of nuclear factor kB (NF-kB) from the cytoplasm to the nucleus inmacrophages derived from a THP-1 human monocyte cell line. Compound 1 acts as a cyclooxygenase (COX-2 and COX-1) inhibitor with higher selectivity toward COX-2 than indomethacin. Pretreatment of cells by 1 shifted the peak in an regulatory gene zinc-finger protein 36 (ZFP36) expression assay. This natural product has noticeable antiinflammatory properties, suggesting that 1 potentially could be used for development as a nonsteroidal anti-inflammatory drug lead.
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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