In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E-2 biosynthesis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F09%3A00335925" target="_blank" >RIV/61389030:_____/09:00335925 - isvavai.cz</a>
Alternative codes found
RIV/60460709:41610/09:29798
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E-2 biosynthesis
Original language description
Possible anti-inflammatory effect of carvacrol was evaluated by in vitro cyclooxygenase-2 (COX-2) assay. Carvacrol inhibited production of prostaglandin E-2 catalysed by COX-2 with an IC50 value of 0.8 mu M what is practically the same concentration as the IC50 obtained for the standard inhibitors indomethacin and NS-398 with values of 0.7 mu M and 0.8 mu M, respectively. The COX-1 was inhibited approximately at the same rate (IC50 of 0.7 mu M for carvacrol), which suggests non-selective inhibition of both enzyme isoforms. The results of the study demonstrate possible anti-inflammatory potential of this compound due to the inhibition of inducible COX-2 isoform.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
GM - Food industry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Archives of Pharmacal Research
ISSN
0253-6269
e-ISSN
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Volume of the periodical
32
Issue of the periodical within the volume
1
Country of publishing house
KR - KOREA, REPUBLIC OF
Number of pages
4
Pages from-to
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UT code for WoS article
000262851700010
EID of the result in the Scopus database
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